AN UNBIASED VIEW OF LDN-27219 AS A CANCER DRUG CANDIDATE

Just one specially appealing compound is LDN-27219. Even though most tTG inhibitors are created to bind towards the protein crosslinking Energetic web site, LDN-27219 rather binds to the nucleotide binding pocket with the enzyme even though it really is in its closed-condition conformation, and stabilizes that conformation to stop crosslinking acti